TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells

Mutations in the polycystins cause autosomal dominant polycystic kidney disease (ADPKD). Here we show that transmembrane protein 33 (TMEM33) interacts with the ion channel polycystin-2 (PC2) at the endoplasmic reticulum (ER) membrane, enhancing its opening over the whole physiological calcium range...

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Detalles Bibliográficos
Autores principales: Arhatte, Malika, Gunaratne, Gihan S., El Boustany, Charbel, Kuo, Ivana Y., Moro, Céline, Duprat, Fabrice, Plaisant, Magali, Duval, Hélène, Li, Dahui, Picard, Nicolas, Couvreux, Anais, Duranton, Christophe, Rubera, Isabelle, Pagnotta, Sophie, Lacas-Gervais, Sandra, Ehrlich, Barbara E., Marchant, Jonathan S., Savage, Aaron M., van Eeden, Fredericus J. M., Wilkinson, Robert N., Demolombe, Sophie, Honoré, Eric, Patel, Amanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497644/
https://www.ncbi.nlm.nih.gov/pubmed/31048699
http://dx.doi.org/10.1038/s41467-019-10045-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497644/
https://www.ncbi.nlm.nih.gov/pubmed/31048699
http://dx.doi.org/10.1038/s41467-019-10045-y

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