Cargando…

Computational prediction and in vitro validation of VEGFR1 as a novel protein target for 2,3,7,8-tetrachlorodibenzo-p-dioxin

The toxic manifestations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an environmental contaminant, primarily depend on its ability to activate aryl hydrocarbon receptor (AhR), which is a ligand-dependent transcription factor belonging to the superfamily of basic-helix-loop-helix DNA-binding prote...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chitrala, Kumaraswamy Naidu, Yang, Xiaoming, Busbee, Brandon, Singh, Narendra P., Bonati, Laura, Xing, Yongna, Nagarkatti, Prakash, Nagarkatti, Mitzi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497656/ https://www.ncbi.nlm.nih.gov/pubmed/31048752 http://dx.doi.org/10.1038/s41598-019-43232-4

Ejemplares similares

2,3,7,8-Tetrachlorodibenzo-p-dioxin induces multigenerational alterations in the expression of microRNA in the thymus through epigenetic modifications
por: Singh, Narendra P, et al.
Publicado: (2022)

AhR Activation by TCDD (2,3,7,8-Tetrachlorodibenzo-p-dioxin) Attenuates Pertussis Toxin-Induced Inflammatory Responses by Differential Regulation of Tregs and Th17 Cells Through Specific Targeting by microRNA
por: Al-Ghezi, Zinah Zamil, et al.
Publicado: (2019)

Effects of Acute 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Exposure on the Circulating and Cecal Metabolome Profile
por: Dopkins, Nicholas, et al.
Publicado: (2021)

Resveratrol Attenuates 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Mediated Induction of Myeloid-Derived Suppressor Cells (MDSC) and Their Functions
por: Neamah, Wurood Hantoosh, et al.
Publicado: (2023)

Alterations in the Gut Microbiome and Suppression of Histone Deacetylases by Resveratrol Are Associated with Attenuation of Colonic Inflammation and Protection Against Colorectal Cancer
por: Alrafas, Haider Rasheed, et al.
Publicado: (2020)

Comparative analysis of interactions between aryl hydrocarbon receptor ligand binding domain with its ligands: a computational study
por: Chitrala, Kumaraswamy Naidu, et al.
Publicado: (2018)

Prediction of Possible Biomarkers and Novel Pathways Conferring Risk to Post-Traumatic Stress Disorder
por: Chitrala, Kumaraswamy Naidu, et al.
Publicado: (2016)

Analysis of the TP53 Deleterious Single Nucleotide Polymorphisms Impact on Estrogen Receptor Alpha-p53 Interaction: A Machine Learning Approach
por: Chitrala, Kumaraswamy Naidu, et al.
Publicado: (2019)

Studies on the bioaccumulation and microbial degradation of 2,3,7,8-tetrachlorodibenzo-p-dioxin.
por: Matsumura, F, et al.
Publicado: (1973)

Pathologic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals.
por: Gupta, B N, et al.
Publicado: (1973)

Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in aquatic organisms.
por: Miller, R A, et al.
Publicado: (1973)

Excretion and tissue distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat.
por: Piper, W N, et al.
Publicado: (1973)

Postnatal effects of maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
por: Moore, J A, et al.
Publicado: (1973)

Synthesis of new steric and electronic analogs of 2,3,7,8-tetrachlorodibenzo-p-dioxin.
por: Kende, A S, et al.
Publicado: (1973)

Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the immune system of laboratory animals.
por: Vos, J G, et al.
Publicado: (1973)

2,3,7,8-Tetrachlorodibenzo-p-dioxin modifies alternative splicing in mouse liver
por: Villaseñor-Altamirano, Ana B., et al.
Publicado: (2019)

Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: clinical and laboratory effects.
por: Geusau, A, et al.
Publicado: (2001)

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin upon hemostasis and hematologic function in the rat.
por: Weissberg, J B, et al.
Publicado: (1973)

Hematologic and clinical chemistry effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals.
por: Zinkl, J G, et al.
Publicado: (1973)

Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the biliary excretion of indocyanine green in rat.
por: Hwang, S W
Publicado: (1973)

Mortality Rates Among Trichlorophenol Workers With Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin
por: Collins, James J., et al.
Publicado: (2009)

Plasma Cytokine Concentrations in Workers Exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
por: Saberi Hosnijeh, Fatemeh, et al.
Publicado: (2012)

AHR-dependent changes in the mitochondrial proteome in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin
por: Hwang, Hye Jin, et al.
Publicado: (2016)

Theoretical Investigations on the Reactivity of Hydrogen Peroxide toward 2,3,7,8-Tetrachlorodibenzo-p-dioxin
por: Wang, Weihua, et al.
Publicado: (2018)

Age at menarche in Seveso daughters exposed in utero to 2,3,7,8-tetrachlorodibenzo-p-dioxin
por: Warner, Marcella, et al.
Publicado: (2020)

Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on T Cell Differentiation in Primary Biliary Cholangitis
por: She, Chunhui, et al.
Publicado: (2020)

Transcriptomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in liver: Comparison of rat and mouse
por: Boutros, Paul C, et al.
Publicado: (2008)

2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure Prevents Cardiac Valve Formation in Developing Zebrafish
por: Mehta, Vatsal, et al.
Publicado: (2008)

Development of bioassays and approaches for the risk assessment of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds.
por: Safe, S
Publicado: (1993)

Spontaneous abortion, sex ratio, and paternal occupational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
por: Schnorr, T M, et al.
Publicado: (2001)

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on drug metabolism and hepatic microsomes of rats and mice.
por: Greig, J B, et al.
Publicado: (1973)

Evaluation of cardiovascular outcomes among U.S. workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
por: Calvert, G M, et al.
Publicado: (1998)

Immunologic findings in workers formerly exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and its congeners.
por: Jung, D, et al.
Publicado: (1998)

2,3,7,8-Tetrachlorodibenzo-p-dioxin plasma levels in Seveso 20 years after the accident.
por: Landi, M T, et al.
Publicado: (1998)

In Utero Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Affects the Development of Reproductive System in Mouse
por: Jin, Mei Hua, et al.
Publicado: (2008)

Influence of Maternal Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Socioemotional Behaviors in Offspring Rats
por: Nguyen, Anh T.N., et al.
Publicado: (2013)

The growth and infectivity of Leishmania major is not altered by in vitro exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
por: Sazhnev, Vera, et al.
Publicado: (2018)

2,3,7,8-Tetrachlorodibenzo-p-dioxin abolishes circadian regulation of hepatic metabolic activity in mice
por: Fader, Kelly A., et al.
Publicado: (2019)

Single-Nuclei RNA Sequencing Assessment of the Hepatic Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin
por: Nault, Rance, et al.
Publicado: (2020)

α-Tocopherol restores semen quality in rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
por: Wurlina, Wurlina, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_pv1oq16ub2gs5jgi4cf29ofho6