Intrathecal TRPM8 blocking attenuates cold hyperalgesia via PKC and NF-κB signaling in the dorsal root ganglion of rats with neuropathic pain

Background: TRPM8 channel plays central roles in the sensitization of nociceptive transduction and is thought as one of the potential targets for the treatment of neuropathic pain. However, the specific molecular mechanisms are still less clear. Methods: Sciatic chronic constriction injury (CCI) rat...

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Detalles Bibliográficos
Autores principales: Cao, Song, Li, Qingmei, Hou, Jingfeng, Li, Zhourui, Cao, Xinya, Liu, Xiaohong, Qin, Bangyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497852/
https://www.ncbi.nlm.nih.gov/pubmed/31114308
http://dx.doi.org/10.2147/JPR.S197168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497852/
https://www.ncbi.nlm.nih.gov/pubmed/31114308
http://dx.doi.org/10.2147/JPR.S197168

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