Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers

The cellular prion protein (PrP(C)) is a key neuronal receptor for β-amyloid oligomers (AβO), mediating their neurotoxicity, which contributes to the neurodegeneration in Alzheimer's disease (AD). Similarly to the amyloid precursor protein (APP), PrP(C) is proteolytically cleaved from the cell...

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Detalles Bibliográficos
Autores principales: Jarosz-Griffiths, Heledd H., Corbett, Nicola J., Rowland, Helen A., Fisher, Kate, Jones, Alys C., Baron, Jennifer, Howell, Gareth J., Cowley, Sally A., Chintawar, Satyan, Cader, M. Zameel, Kellett, Katherine A. B., Hooper, Nigel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Neurobiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497954/
https://www.ncbi.nlm.nih.gov/pubmed/30872401
http://dx.doi.org/10.1074/jbc.RA118.005364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497954/
https://www.ncbi.nlm.nih.gov/pubmed/30872401
http://dx.doi.org/10.1074/jbc.RA118.005364

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