Human Double-Negative Regulatory T-Cells Induce a Metabolic and Functional Switch in Effector T-Cells by Suppressing mTOR Activity

The recently discovered population of TCRαβ+ CD4–/CD8– (double-negative, DN) T-cells are highly potent suppressor cells in mice and humans. In preclinical transplantation models, adoptive transfer of DN T-cells specifically inhibits alloreactive T-cells and prevents transplant rejection or graft-vs....

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Detalles Bibliográficos
Autores principales: Haug, Tabea, Aigner, Michael, Peuser, Moritz M., Strobl, Carolin D., Hildner, Kai, Mougiakakos, Dimitrios, Bruns, Heiko, Mackensen, Andreas, Völkl, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498403/
https://www.ncbi.nlm.nih.gov/pubmed/31105702
http://dx.doi.org/10.3389/fimmu.2019.00883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498403/
https://www.ncbi.nlm.nih.gov/pubmed/31105702
http://dx.doi.org/10.3389/fimmu.2019.00883

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