Boosting the biosynthesis of betulinic acid and related triterpenoids in Yarrowia lipolytica via multimodular metabolic engineering

BACKGROUND: Betulinic acid is a pentacyclic lupane-type triterpenoid and a potential antiviral and antitumor drug, but the amount of betulinic acid in plants is low and cannot meet the demand for this compound. Yarrowia lipolytica, as an oleaginous yeast, is a promising microbial cell factory for th...

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Detalles Bibliográficos
Autores principales: Jin, Cong-Cong, Zhang, Jin-Lai, Song, Hao, Cao, Ying-Xiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498500/
https://www.ncbi.nlm.nih.gov/pubmed/31053076
http://dx.doi.org/10.1186/s12934-019-1127-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498500/
https://www.ncbi.nlm.nih.gov/pubmed/31053076
http://dx.doi.org/10.1186/s12934-019-1127-8

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