Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR

BACKGROUND: In the event of amino acid starvation, the cell activates two main protective pathways: Amino Acid starvation Response (AAR), to inhibit global translation, and autophagy, to recover the essential substrates from degradation of redundant self-components. Whether and how AAR and autophagy...

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Detalles Bibliográficos
Autores principales: Follo, Carlo, Vidoni, Chiara, Morani, Federica, Ferraresi, Alessandra, Seca, Christian, Isidoro, Ciro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498594/
https://www.ncbi.nlm.nih.gov/pubmed/31046771
http://dx.doi.org/10.1186/s12964-019-0354-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498594/
https://www.ncbi.nlm.nih.gov/pubmed/31046771
http://dx.doi.org/10.1186/s12964-019-0354-2

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