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Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR

BACKGROUND: In the event of amino acid starvation, the cell activates two main protective pathways: Amino Acid starvation Response (AAR), to inhibit global translation, and autophagy, to recover the essential substrates from degradation of redundant self-components. Whether and how AAR and autophagy...

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Detalles Bibliográficos
Autores principales:	Follo, Carlo, Vidoni, Chiara, Morani, Federica, Ferraresi, Alessandra, Seca, Christian, Isidoro, Ciro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498594/ https://www.ncbi.nlm.nih.gov/pubmed/31046771 http://dx.doi.org/10.1186/s12964-019-0354-2

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