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Integration of the Deacetylase SIRT1 in the Response to Nucleolar Stress: Metabolic Implications for Neurodegenerative Diseases

Understanding underlying mechanisms of neurodegenerative diseases is fundamental to develop effective therapeutic intervention. Yet they remain largely elusive, but metabolic, and transcriptional dysregulation are common events. Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD(+))-depen...

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Detalles Bibliográficos
Autores principales: Kreiner, Grzegorz, Sönmez, Aynur, Liss, Birgit, Parlato, Rosanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499230/
https://www.ncbi.nlm.nih.gov/pubmed/31110473
http://dx.doi.org/10.3389/fnmol.2019.00106