NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction

The exosome functions in the degradation of diverse RNA species, yet how it is negatively regulated remains largely unknown. Here, we show that NRDE2 forms a 1:1 complex with MTR4, a nuclear exosome cofactor critical for exosome recruitment, via a conserved MTR4-interacting domain (MID). Unexpectedl...

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Detalles Bibliográficos
Autores principales: Wang, Jianshu, Chen, Jiyun, Wu, Guifen, Zhang, Hongling, Du, Xian, Chen, Suli, Zhang, Li, Wang, Ke, Fan, Jing, Gao, Shuaixin, Wu, Xudong, Zhang, Shouxiang, Kuai, Bin, Zhao, Peng, Chi, Binkai, Wang, Lantian, Li, Guohui, Wong, Catherine C.L., Zhou, Yu, Li, Jinsong, Yun, Caihong, Cheng, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499326/
https://www.ncbi.nlm.nih.gov/pubmed/30842217
http://dx.doi.org/10.1101/gad.322602.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499326/
https://www.ncbi.nlm.nih.gov/pubmed/30842217
http://dx.doi.org/10.1101/gad.322602.118

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