An Intramolecular Salt Bridge Linking TDP43 RNA Binding, Protein Stability, and TDP43-Dependent Neurodegeneration

The majority of individuals with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) exhibit neuronal cytoplasmic inclusions rich in the RNA binding protein TDP43. Even so, the relation between the RNA binding properties of TDP43 and neurodegeneration remains obscure. Here, we show...

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Detalles Bibliográficos
Autores principales: Flores, Brittany N., Li, Xingli, Malik, Ahmed M., Martinez, Jose, Beg, Asim A., Barmada, Sami J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499398/
https://www.ncbi.nlm.nih.gov/pubmed/31018129
http://dx.doi.org/10.1016/j.celrep.2019.03.093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499398/
https://www.ncbi.nlm.nih.gov/pubmed/31018129
http://dx.doi.org/10.1016/j.celrep.2019.03.093

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