Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

PD-L1 on the surface of tumor cells binds its receptor PD-1 on effector T cells, thereby suppressing their activity. Antibody blockade of PD-L1 can activate an anti-tumor immune response leading to durable remissions in a subset of cancer patients. Here, we describe an alternative mechanism of PD-L1...

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Detalles Bibliográficos
Autores principales: Poggio, Mauro, Hu, Tianyi, Pai, Chien-Chun, Chu, Brandon, Belair, Cassandra D., Chang, Anthony, Montabana, Elizabeth, Lang, Ursula E., Fu, Qi, Fong, Lawrence, Blelloch, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499401/
https://www.ncbi.nlm.nih.gov/pubmed/30951669
http://dx.doi.org/10.1016/j.cell.2019.02.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499401/
https://www.ncbi.nlm.nih.gov/pubmed/30951669
http://dx.doi.org/10.1016/j.cell.2019.02.016

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