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Relationship between single nucleotide polymorphisms in the 3′UTR of amyloid precursor protein and risk of Alzheimer’s disease and its mechanism

Background and objective: Deregulation of the expression of amyloid precursor protein (APP) can lead to the development of Alzheimer’s disease (AD). Recent studies have shown that many single nucleotide polymorphisms (SNPs) in the 3′ untranslated region (UTR) of APP are associated with the developme...

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Detalles Bibliográficos
Autores principales: Zhou, Qiong, Luo, Lian, Wang, Xiaohang, Li, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499457/
https://www.ncbi.nlm.nih.gov/pubmed/30914454
http://dx.doi.org/10.1042/BSR20182485