Cell cycle plasticity driven by MTOR signaling: Integral resistance to CDK4/6 inhibition in patient-derived models of pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC), like many KRAS-driven tumors, preferentially loses CDKN2A that encodes an endogenous CDK4/6 inhibitor to bypass the RB-mediated cell cycle suppression. Analysis of a panel of patient-derived cell lines and matched xenografts indicated that many pancreatic can...

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Detalles Bibliográficos
Autores principales: Knudsen, Erik S., Kumarasamy, Vishnu, Ruiz, Amanda, Sivinski, Jared, Chung, Sejin, Grant, Adam, Vail, Paris, Chauhan, Shailender S., Jie, Tun, Riall, Taylor S., Witkiewicz, Agnieszka K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499706/
https://www.ncbi.nlm.nih.gov/pubmed/30696953
http://dx.doi.org/10.1038/s41388-018-0650-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499706/
https://www.ncbi.nlm.nih.gov/pubmed/30696953
http://dx.doi.org/10.1038/s41388-018-0650-0

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