Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis

Impaired neuronal processes, including dopamine imbalance, are central to the pathogenesis of major psychosis, but the molecular origins are unclear. Here we perform a multi-omics study of neurons isolated from the prefrontal cortex in schizophrenia and bipolar disorder (n = 55 cases and 27 controls...

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Detalles Bibliográficos
Autores principales: Pai, Shraddha, Li, Peipei, Killinger, Bryan, Marshall, Lee, Jia, Peixin, Liao, Ji, Petronis, Arturas, Szabó, Piroska E., Labrie, Viviane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499808/
https://www.ncbi.nlm.nih.gov/pubmed/31053723
http://dx.doi.org/10.1038/s41467-019-09786-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499808/
https://www.ncbi.nlm.nih.gov/pubmed/31053723
http://dx.doi.org/10.1038/s41467-019-09786-7

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