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Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis
Impaired neuronal processes, including dopamine imbalance, are central to the pathogenesis of major psychosis, but the molecular origins are unclear. Here we perform a multi-omics study of neurons isolated from the prefrontal cortex in schizophrenia and bipolar disorder (n = 55 cases and 27 controls...
Autores principales: | Pai, Shraddha, Li, Peipei, Killinger, Bryan, Marshall, Lee, Jia, Peixin, Liao, Ji, Petronis, Arturas, Szabó, Piroska E., Labrie, Viviane |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499808/ https://www.ncbi.nlm.nih.gov/pubmed/31053723 http://dx.doi.org/10.1038/s41467-019-09786-7 |
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