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Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins

Autophagy is an essential recycling and quality control pathway. Mammalian ATG8 proteins drive autophagosome formation and selective removal of protein aggregates and organelles by recruiting autophagy receptors and adaptors that contain a LC3-interacting region (LIR) motif. LIR motifs can be highly...

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Detalles Bibliográficos
Autores principales: Wirth, Martina, Zhang, Wenxin, Razi, Minoo, Nyoni, Lynet, Joshi, Dhira, O’Reilly, Nicola, Johansen, Terje, Tooze, Sharon A., Mouilleron, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499816/
https://www.ncbi.nlm.nih.gov/pubmed/31053714
http://dx.doi.org/10.1038/s41467-019-10059-6