Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity

Nephrotoxicity is a critical adverse event that leads to discontinuation of kinase inhibitor (KI) treatment. Here we show, through meta-analyses of FDA Adverse Event Reporting System, that dasatinib is associated with high risk for glomerular toxicity that is uncoupled from hypertension, suggesting...

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Detalles Bibliográficos
Autores principales: Calizo, Rhodora C., Bhattacharya, Smiti, van Hasselt, J. G. Coen, Wei, Chengguo, Wong, Jenny S., Wiener, Robert J., Ge, Xuhua, Wong, Nicholas J., Lee, Jia-Jye, Cuttitta, Christina M., Jayaraman, Gomathi, Au, Vivienne H., Janssen, William, Liu, Tong, Li, Hong, Salem, Fadi, Jaimes, Edgar A., Murphy, Barbara, Campbell, Kirk N., Azeloglu, Evren U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499885/
https://www.ncbi.nlm.nih.gov/pubmed/31053734
http://dx.doi.org/10.1038/s41467-019-09936-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499885/
https://www.ncbi.nlm.nih.gov/pubmed/31053734
http://dx.doi.org/10.1038/s41467-019-09936-x

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