Exogenous expression of the glycosyltransferase LARGE1 restores α-dystroglycan matriglycan and laminin binding in rhabdomyosarcoma

BACKGROUND: α-Dystroglycan is the highly glycosylated component of the dystrophin-glycoprotein complex (DGC) that binds with high-affinity to extracellular matrix (ECM) proteins containing laminin-G-like (LG) domains via a unique heteropolysaccharide [-GlcA-beta1,3-Xyl-alpha1,3-](n) called matriglyc...

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Detalles Bibliográficos
Autores principales: Beltrán, Daniel, Anderson, Mary E., Bharathy, Narendra, Settelmeyer, Teagan P., Svalina, Matthew N., Bajwa, Zia, Shern, John F., Gultekin, Sakir H., Cuellar, Marco A., Yonekawa, Takahiro, Keller, Charles, Campbell, Kevin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500046/
https://www.ncbi.nlm.nih.gov/pubmed/31054580
http://dx.doi.org/10.1186/s13395-019-0195-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500046/
https://www.ncbi.nlm.nih.gov/pubmed/31054580
http://dx.doi.org/10.1186/s13395-019-0195-0

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