Select sequencing of clonally expanded CD8(+) T cells reveals limits to clonal expansion

To permit the recognition of antigens, T cells generate a vast diversity of T cell receptor (TCR) sequences. Upon binding of the TCR to an antigen–MHC complex, T cells clonally expand to establish an immune response. To study antigen-specific T cell clonality, we have developed a method that allows...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Huang, Sikora, Michael J., Islam, Saiful, Chowdhury, Roshni Roy, Chien, Yueh-hsiu, Scriba, Thomas J., Davis, Mark M., Steinmetz, Lars M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500157/
https://www.ncbi.nlm.nih.gov/pubmed/30992377
http://dx.doi.org/10.1073/pnas.1902649116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500157/
https://www.ncbi.nlm.nih.gov/pubmed/30992377
http://dx.doi.org/10.1073/pnas.1902649116

Ejemplares similares