Bromodomain and Extraterminal (BET) Protein Inhibition Restores Redox Balance and Inhibits Myofibroblast Activation

BACKGROUND AND OBJECTIVE: Progressive pulmonary fibrosis is the main cause of death in patients with systemic sclerosis (SSc) with interstitial lung disease (ILD) and in those with idiopathic pulmonary fibrosis (IPF). Transforming growth factor-β (TGF-β) and NADPH oxidase- (NOX-) derived reactive ox...

Descripción completa

Detalles Bibliográficos
Autores principales: Stock, Carmel J. W., Michaeloudes, Charalambos, Leoni, Patricia, Durham, Andrew L., Mumby, Sharon, Wells, Athol U., Chung, Kian Fan, Adcock, Ian M., Renzoni, Elisabetta A., Lindahl, Gisela E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500679/
https://www.ncbi.nlm.nih.gov/pubmed/31119153
http://dx.doi.org/10.1155/2019/1484736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500679/
https://www.ncbi.nlm.nih.gov/pubmed/31119153
http://dx.doi.org/10.1155/2019/1484736

Ejemplares similares