Cargando…

Mutation spectrum of germline cancer susceptibility genes among unselected Chinese colorectal cancer patients

Background: Genetic factors play an important role in colorectal cancer (CRC) risk, yet the prevalence and spectrum of germline cancer susceptibility gene mutations among unselected Chinese CRC patients is largely undetermined. Methods: We performed next-generation sequencing with a 73-genes panel a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gong, Rui, He, Yuan, Liu, Xiao-Yun, Wang, Hai-Yun, Sun, Li-Yue, Yang, Xin-Hua, Li, Bin, Cao, Xin-Kai, Ye, Zu-Lu, Kong, Ling-Heng, Zhang, Da-Dong, Li, Yu-Hong, Xu, Rui-Hua, Shao, Jian-Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500872/ https://www.ncbi.nlm.nih.gov/pubmed/31118792 http://dx.doi.org/10.2147/CMAR.S193985

Ejemplares similares

Profiling Oncogenic Germline Mutations in Unselected Chinese Lung Cancer Patients
por: Yang, Jie, et al.
Publicado: (2021)

Hypermethylation of APC2 Is a Predictive Epigenetic Biomarker for Chinese Colorectal Cancer
por: He, Yuan, et al.
Publicado: (2018)

Burden of hereditary cancer susceptibility in unselected patients with pancreatic ductal adenocarcinoma referred for germline screening
por: Cremin, Carol, et al.
Publicado: (2020)

Germline Cancer Susceptibility Gene Testing in Unselected Patients with Hepatobiliary Cancers: A Multi-Center Prospective Study
por: Uson Junior, Pedro LS, et al.
Publicado: (2022)

Germline pathogenic variants in unselected Korean men with prostate cancer
por: So, Min-Kyung, et al.
Publicado: (2022)

Prevalence and Landscape of Pathogenic or Likely Pathogenic Germline Variants and Their Association With Somatic Phenotype in Unselected Chinese Patients With Gynecologic Cancers
por: Wen, Hao, et al.
Publicado: (2023)

Germline mutational profile of Chinese patients under 70 years old with colorectal cancer
por: Jiang, Teng‐Jia, et al.
Publicado: (2020)

Spectrum of PALB2 germline mutations and characteristics of PALB2‐related breast cancer: Screening of 16,501 unselected patients with breast cancer and 5890 controls by next‐generation sequencing
por: Zhou, Jiaojiao, et al.
Publicado: (2020)

Prevalence and Prognostic Role of BRCA1/2 Variants in Unselected Chinese Breast Cancer Patients
por: Zhong, Xiaorong, et al.
Publicado: (2016)

Clinical Significance of Germline Cancer Predisposing Variants in Unselected Patients with Pancreatic Adenocarcinoma
por: Fountzilas, Elena, et al.
Publicado: (2021)

Comprehensive germline-genomic and clinical profiling in 160 unselected children and adolescents with cancer
por: Wagener, Rabea, et al.
Publicado: (2021)

Prevalence of germline mutations in cancer susceptibility genes in Chinese patients with renal cell carcinoma
por: Feng, Huayi, et al.
Publicado: (2023)

Germline Cancer Testing in Unselected Patients with Gastric and Esophageal Cancers: A Multi-center Prospective Study
por: Uson, P. L. S., et al.
Publicado: (2022)

Spectrum of germline cancer susceptibility gene mutations in Turkish colorectal cancer patients: a single center study
por: ERDEM, Haktan Bağış, et al.
Publicado: (2020)

Prevalence of pathogenic germline variants detected by multigene sequencing in unselected Japanese patients with ovarian cancer
por: Hirasawa, Akira, et al.
Publicado: (2017)

Comparison of BRCA versus non-BRCA germline mutations and associated somatic mutation profiles in patients with unselected breast cancer
por: Chen, Bo, et al.
Publicado: (2020)

Prevalence and reclassification of BRCA1 and BRCA2 variants in a large, unselected Chinese Han breast cancer cohort
por: Liu, Yun, et al.
Publicado: (2021)

Association Study of Germline Variants in CCNB1 and CDK1 with Breast Cancer Susceptibility, Progression, and Survival among Chinese Han Women
por: Li, Yan, et al.
Publicado: (2013)

Prevalence of BRCA1 and BRCA2 germline variants in an unselected pancreatic cancer patient cohort in Pakistan
por: Muhammad, Noor, et al.
Publicado: (2023)

Clinical Significance of Germline Pathogenic Variants among 51 Cancer Predisposition Genes in an Unselected Cohort of Italian Pancreatic Cancer Patients
por: Puccini, Alberto, et al.
Publicado: (2022)

Pathologic response after preoperative therapy predicts prognosis of Chinese colorectal cancer patients with liver metastases
por: Wang, Yun, et al.
Publicado: (2017)

Prevalence and Spectrum of Predisposition Genes With Germline Mutations Among Chinese Patients With Bowel Cancer
por: Xie, Zhengyong, et al.
Publicado: (2022)

Germline MUTYH gene mutations are not frequently found in unselected patients with papillary breast carcinoma
por: Boesaard, Ewout P, et al.
Publicado: (2014)

Clinical and genomic features of Chinese lung cancer patients with germline mutations
por: Peng, Wenying, et al.
Publicado: (2022)

Primary tumor immune score fails to predict the prognosis of colorectal cancer liver metastases after hepatectomy in Chinese populations
por: Lin, Hao-Cheng, et al.
Publicado: (2021)

Validation of the European Organization for Research and Treatment of Cancer cervical cancer module for Chinese patients with cervical cancer
por: Hua, Cai-Hong, et al.
Publicado: (2013)

The contribution of hereditary cancer-related germline mutations to lung cancer susceptibility
por: Liu, Mengyuan, et al.
Publicado: (2020)

Polymorphisms in the XPC gene and gastric cancer susceptibility in a Southern Chinese population
por: Hua, Rui-Xi, et al.
Publicado: (2016)

Role of capecitabine in treating metastatic colorectal cancer in Chinese patients
por: Wang, Feng, et al.
Publicado: (2014)

Spectrum of germline mutations in RB1 in Chinese patients with retinoblastoma: Application of targeted next-generation sequencing
por: Zou, Yihua, et al.
Publicado: (2021)

Frequency and Clinical Characteristics of Unselected Korean Gastric Cancer Patients with a Germline CDH1 V832M Mutation
por: Shin, Saeam, et al.
Publicado: (2020)

Universal Germline Testing of Unselected Cancer Patients Detects Pathogenic Variants Missed by Standard Guidelines without Increasing Healthcare Costs
por: Perkins, Adrienne T., et al.
Publicado: (2021)

PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population
por: Qiu, Li-Xin, et al.
Publicado: (2016)

Association of HMGB1 Gene Polymorphisms with Risk of Colorectal Cancer in a Chinese Population
por: Wang, Jian-Xin, et al.
Publicado: (2016)

BRCAsearch: written pre-test information and BRCA1/2 germline mutation testing in unselected patients with newly diagnosed breast cancer
por: Nilsson, Martin P., et al.
Publicado: (2017)

Clinical characteristics and survival analysis of Chinese ovarian cancer patients with RAD51D germline mutations
por: Yao, Hongwen, et al.
Publicado: (2022)

Detection of mismatch repair gene germline mutation carrier among Chinese population with colorectal cancer
por: Jin, Hei-Ying, et al.
Publicado: (2008)

Cancer experience in the relatives of an unselected series of breast cancer patients.
por: Teare, M. D., et al.
Publicado: (1994)

Phase II study of oxaliplatin combined with S-1 and leucovorin (SOL) for Chinese patients with metastatic colorectal cancer
por: Wang, Zhi-Qiang, et al.
Publicado: (2016)

Genetic variants in the nucleotide excision repair pathway genes and gastric cancer susceptibility in a southern Chinese population
por: He, Jing, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_opbtc8a5k8rlbn3o1mgbtjqocq