SCRABBLE: single-cell RNA-seq imputation constrained by bulk RNA-seq data

Single-cell RNA-seq data contain a large proportion of zeros for expressed genes. Such dropout events present a fundamental challenge for various types of data analyses. Here, we describe the SCRABBLE algorithm to address this problem. SCRABBLE leverages bulk data as a constraint and reduces unwante...

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Detalles Bibliográficos
Autores principales: Peng, Tao, Zhu, Qin, Yin, Penghang, Tan, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501316/
https://www.ncbi.nlm.nih.gov/pubmed/31060596
http://dx.doi.org/10.1186/s13059-019-1681-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501316/
https://www.ncbi.nlm.nih.gov/pubmed/31060596
http://dx.doi.org/10.1186/s13059-019-1681-8

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