Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells

BACKGROUND: DNA methyltransferases (DNMTs) are epigenetic enzymes involved in embryonic development, cell differentiation, epithelial to mesenchymal transition, and control of gene expression, whose overexpression or enhanced catalytic activity has been widely reported in cancer initiation and progr...

Descripción completa

Detalles Bibliográficos
Autores principales: Zwergel, Clemens, Schnekenburger, Michael, Sarno, Federica, Battistelli, Cecilia, Manara, Maria Cristina, Stazi, Giulia, Mazzone, Roberta, Fioravanti, Rossella, Gros, Christina, Ausseil, Frédéric, Florean, Cristina, Nebbioso, Angela, Strippoli, Raffaele, Ushijima, Toshikazu, Scotlandi, Katia, Tripodi, Marco, Arimondo, Paola B., Altucci, Lucia, Diederich, Marc, Mai, Antonello, Valente, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501426/
https://www.ncbi.nlm.nih.gov/pubmed/31060628
http://dx.doi.org/10.1186/s13148-019-0663-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501426/
https://www.ncbi.nlm.nih.gov/pubmed/31060628
http://dx.doi.org/10.1186/s13148-019-0663-8

Ejemplares similares