Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping

Structure-guided drug discovery emerged in the 1970s and 1980s, stimulated by the three-dimensional structures of protein targets that became available, mainly through X-ray crystal structure analysis, assisted by the development of synchrotron radiation sources. Structures of known drugs or inhibit...

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Detalles Bibliográficos
Autores principales: Thomas, Sherine E., Collins, Patrick, James, Rory Hennell, Mendes, Vitor, Charoensutthivarakul, Sitthivut, Radoux, Chris, Abell, Chris, Coyne, Anthony G., Floto, R. Andres, von Delft, Frank, Blundell, Tom L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society Publishing 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501894/
https://www.ncbi.nlm.nih.gov/pubmed/31030650
http://dx.doi.org/10.1098/rsta.2018.0422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501894/
https://www.ncbi.nlm.nih.gov/pubmed/31030650
http://dx.doi.org/10.1098/rsta.2018.0422

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