Dopamine receptor antagonists as potential therapeutic agents for ADPKD

Autosomal dominant polycystic kidney disease (ADPKD) is caused mostly by mutations in polycystin-1 or polycystin-2. Fluid flow leads to polycystin-dependent calcium influx and nuclear export of histone deacetylase 5 (HDAC5), which facilitates the maintenance of renal epithelial architecture by de-re...

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Detalles Bibliográficos
Autores principales: Paul, Parama, Ramachandran, Sreekumar, Xia, Sheng, Unruh, Jay R., Conkright-Fincham, Juliana, Li, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502331/
https://www.ncbi.nlm.nih.gov/pubmed/31059522
http://dx.doi.org/10.1371/journal.pone.0216220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502331/
https://www.ncbi.nlm.nih.gov/pubmed/31059522
http://dx.doi.org/10.1371/journal.pone.0216220

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