LINE-1 hypomethylation in human hepatocellular carcinomas correlates with shorter overall survival and CIMP phenotype

Reactivation of interspersed repetitive sequences due to loss of methylation is associated with genomic instability, one of the hallmarks of cancer cells. LINE-1 hypomethylation is a surrogate marker for global methylation loss and is potentially a new diagnostic and prognostic biomarker in tumors....

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Detalles Bibliográficos
Autores principales: Anwar, Sumadi Lukman, Hasemeier, Britta, Schipper, Elisa, Vogel, Arndt, Kreipe, Hans, Lehmann, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502450/
https://www.ncbi.nlm.nih.gov/pubmed/31059558
http://dx.doi.org/10.1371/journal.pone.0216374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502450/
https://www.ncbi.nlm.nih.gov/pubmed/31059558
http://dx.doi.org/10.1371/journal.pone.0216374

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