In vitro evolution of enhanced RNA replicons for immunotherapy

Self-replicating (replicon) RNA is a promising new platform for gene therapy, but applications are still limited by short persistence of expression in most cell types and low levels of transgene expression in vivo. To address these shortcomings, we developed an in vitro evolution strategy and identi...

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Detalles Bibliográficos
Autores principales: Li, Yingzhong, Teague, Brian, Zhang, Yuan, Su, Zhijun, Porter, Ely, Dobosh, Brian, Wagner, Tyler, Irvine, Darrell J., Weiss, Ron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502795/
https://www.ncbi.nlm.nih.gov/pubmed/31061426
http://dx.doi.org/10.1038/s41598-019-43422-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502795/
https://www.ncbi.nlm.nih.gov/pubmed/31061426
http://dx.doi.org/10.1038/s41598-019-43422-0

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