Environmental contaminants modulate the transcriptional activity of polar bear (Ursus maritimus) and human peroxisome proliferator-activated receptor alpha (PPARA)

Peroxisome proliferator-activated receptor alfa (PPARA/NR1C1) is a ligand activated nuclear receptor that is a key regulator of lipid metabolism in tissues with high fatty acid catabolism such as the liver. Here, we cloned PPARA from polar bear liver tissue and studied in vitro transactivation of po...

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Detalles Bibliográficos
Autores principales: Routti, Heli, Berg, Mari K., Lille-Langøy, Roger, Øygarden, Lene, Harju, Mikael, Dietz, Rune, Sonne, Christian, Goksøyr, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502799/
https://www.ncbi.nlm.nih.gov/pubmed/31061404
http://dx.doi.org/10.1038/s41598-019-43337-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502799/
https://www.ncbi.nlm.nih.gov/pubmed/31061404
http://dx.doi.org/10.1038/s41598-019-43337-w

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