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Low potential enzymatic hydride transfer via highly cooperative and inversely functionalized flavin cofactors

Hydride transfers play a crucial role in a multitude of biological redox reactions and are mediated by flavin, deazaflavin or nicotinamide adenine dinucleotide cofactors at standard redox potentials ranging from 0 to –340 mV. 2-Naphthoyl-CoA reductase, a key enzyme of oxygen-independent bacterial na...

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Detalles Bibliográficos
Autores principales: Willistein, Max, Bechtel, Dominique F., Müller, Christina S., Demmer, Ulrike, Heimann, Larissa, Kayastha, Kanwal, Schünemann, Volker, Pierik, Antonio J., Ullmann, G. Matthias, Ermler, Ulrich, Boll, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502838/
https://www.ncbi.nlm.nih.gov/pubmed/31061390
http://dx.doi.org/10.1038/s41467-019-10078-3