Bile-duct proliferation as an unexpected side-effect after AAV2-LDLR gene transfer to rabbit liver
Familial hypercholesterolemia (FH) is an inherited disease of lipoprotein metabolism caused by a defect in the LDL receptor (LDLR) leading to severe hypercholesterolemia, and associated with an increased risk of coronary heart disease and myocardial infarction. We have developed a gene therapy proto...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502883/ https://www.ncbi.nlm.nih.gov/pubmed/31061510 http://dx.doi.org/10.1038/s41598-019-43459-1 |