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Clonal Cell Proliferation in Paroxysmal Nocturnal Hemoglobinuria: Evaluation of PIGA Mutations and T-cell Receptor Clonality

BACKGROUND: Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired pluripotent hematopoietic stem cell disorder associated with an increase in the number of glycosyl-phosphatidyl inositol (GPI)-deficient blood cells. We investigated PNH clonal proliferation in the three cell lineages—granulocytes,...

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Detalles Bibliográficos
Autores principales: Park, Joonhong, Kim, Myungshin, Kim, Yonggoo, Han, Kyungja, Chung, Nack-Gyun, Cho, Bin, Lee, Sung-Eun, Lee, Jong Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Laboratory Medicine 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502953/
https://www.ncbi.nlm.nih.gov/pubmed/31037862
http://dx.doi.org/10.3343/alm.2019.39.5.438