HDAC4 mutations cause diabetes and induce β‐cell FoxO1 nuclear exclusion

BACKGROUND: Studying patients with rare Mendelian diabetes has uncovered molecular mechanisms regulating β‐cell pathophysiology. Previous studies have shown that Class IIa histone deacetylases (HDAC4, 5, 7, and 9) modulate mammalian pancreatic endocrine cell function and glucose homeostasis. METHODS...

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Detalles Bibliográficos
Autores principales: Gong, Maolian, Yu, Yong, Liang, Lei, Vuralli, Dogus, Froehler, Sebastian, Kuehnen, Peter, Du Bois, Philipp, Zhang, Jingjing, Cao, Aidi, Liu, Yuantao, Hussain, Khalid, Fielitz, Jens, Jia, Shiqi, Chen, Wei, Raile, Klemens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503015/
https://www.ncbi.nlm.nih.gov/pubmed/30968599
http://dx.doi.org/10.1002/mgg3.602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503015/
https://www.ncbi.nlm.nih.gov/pubmed/30968599
http://dx.doi.org/10.1002/mgg3.602

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