Tumor genomic alterations in severe-combined immunodeficiency bare-lymphocyte syndrome genes are associated with high mutational burden and disproportional neo-antigen rates

The progression of cancer requires mutational adaptation to permit unrestrained proliferation. A fraction of cancer mutations are oncogenic drivers, while others are putative ‘passengers’ that do not contribute to oncogenesis. However, altered peptides arising from passenger mutations may bind MHCs...

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Detalles Bibliográficos
Autores principales: Wang, Yu, Johnson, Douglas B., Lu, Steve, Diaz, Luis A., Xu, Yaomin, Balko, Justin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503546/
https://www.ncbi.nlm.nih.gov/pubmed/31064401
http://dx.doi.org/10.1186/s40425-019-0584-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503546/
https://www.ncbi.nlm.nih.gov/pubmed/31064401
http://dx.doi.org/10.1186/s40425-019-0584-2

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