Cargando…

BET Bromodomain Inhibitors Suppress Inflammatory Activation of Gingival Fibroblasts and Epithelial Cells From Periodontitis Patients

BET bromodomain proteins are important epigenetic regulators of gene expression that bind acetylated histone tails and regulate the formation of acetylation-dependent chromatin complexes. BET inhibitors suppress inflammatory responses in multiple cell types and animal models, and protect against bon...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maksylewicz, Anna, Bysiek, Agnieszka, Lagosz, Katarzyna B., Macina, Justyna M., Kantorowicz, Malgorzata, Bereta, Grzegorz, Sochalska, Maja, Gawron, Katarzyna, Chomyszyn-Gajewska, Maria, Potempa, Jan, Grabiec, Aleksander M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503739/ https://www.ncbi.nlm.nih.gov/pubmed/31114581 http://dx.doi.org/10.3389/fimmu.2019.00933

Ejemplares similares

HDAC3 Regulates Gingival Fibroblast Inflammatory Responses in Periodontitis
por: Lagosz, K.B., et al.
Publicado: (2019)

Mapping of DNA methylation-sensitive cellular processes in gingival and periodontal ligament fibroblasts in the context of periodontal tissue homeostasis
por: Lagosz-Cwik, Katarzyna B., et al.
Publicado: (2023)

Gingival fibromatosis: clinical, molecular and therapeutic issues
por: Gawron, Katarzyna, et al.
Publicado: (2016)

Gingival Fibromatosis with Significant De Novo Formation of Fibrotic Tissue and a High Rate of Recurrence
por: Gawron, Katarzyna, et al.
Publicado: (2016)

hTERT-immortalized gingival fibroblasts respond to cytokines but fail to mimic primary cell responses to Porphyromonas gingivalis
por: Lagosz-Cwik, Katarzyna B., et al.
Publicado: (2021)

TLR2 Activation by Porphyromonas gingivalis Requires Both PPAD Activity and Fimbriae
por: Wielento, Aleksandra, et al.
Publicado: (2022)

Host and bacterial factors linking periodontitis and rheumatoid arthritis
por: Krutyhołowa, Anna, et al.
Publicado: (2022)

Manipulation of Neutrophils by Porphyromonas gingivalis in the Development of Periodontitis
por: Sochalska, Maja, et al.
Publicado: (2017)

Application of the In Vitro HoxB8 Model System to Characterize the Contributions of Neutrophil–LPS Interaction to Periodontal Disease
por: Sochalska, Maja, et al.
Publicado: (2020)

Candida albicans Shields the Periodontal Killer Porphyromonas gingivalis from Recognition by the Host Immune System and Supports the Bacterial Infection of Gingival Tissue
por: Bartnicka, Dominika, et al.
Publicado: (2020)

Clinics and genetic background of hereditary gingival fibromatosis
por: Strzelec, Karolina, et al.
Publicado: (2021)

Uncovering the Oral Dysbiotic Microbiota as Masters of Neutrophil Responses in the Pathobiology of Periodontitis
por: Prucsi, Zsombor, et al.
Publicado: (2021)

Selective inhibition of BET bromodomains
por: Filippakopoulos, Panagis, et al.
Publicado: (2010)

Epigenetic regulation of inflammation in periodontitis: cellular mechanisms and therapeutic potential
por: Jurdziński, Krzysztof T., et al.
Publicado: (2020)

Targeting BET bromodomain proteins in solid tumors
por: Sahai, Vaibhav, et al.
Publicado: (2016)

Porphyromonas gingivalis Peptidyl Arginine Deiminase (PPAD) in the Context of the Feed-Forward Loop of Inflammation in Periodontitis
por: Prucsi, Zsombor, et al.
Publicado: (2023)

BET bromodomain proteins are required for glioblastoma cell proliferation
por: Pastori, Chiara, et al.
Publicado: (2014)

When are the BET factors the most sensitive to bromodomain inhibitors?
por: Khochbin, Saadi
Publicado: (2013)

Bromodomain Blockade for Intimal Hyperplasia — A Good BET?
por: Ostriker, Allison C., et al.
Publicado: (2015)

BET bromodomain inhibitor (JQ1) and tumor angiogenesis
por: Bid, Hemant Kumar, et al.
Publicado: (2016)

BET bromodomain inhibitors synergize with ATR inhibitors in melanoma
por: Veppil Muralidharan, Somsundar, et al.
Publicado: (2017)

BET bromodomain inhibitors synergize with ATR inhibitors in melanoma
por: Muralidharan, Somsundar Veppil, et al.
Publicado: (2017)

Chemical probes and inhibitors of bromodomains outside the BET family
por: Moustakim, Moses, et al.
Publicado: (2016)

Selective BET bromodomain inhibition as an antifungal therapeutic strategy
por: Mietton, Flore, et al.
Publicado: (2017)

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains
por: Lambert, Jean-Philippe, et al.
Publicado: (2019)

Immunogenicity of prostate cancer is augmented by BET bromodomain inhibition
por: Mao, Wendy, et al.
Publicado: (2019)

Diabetes Medication Metformin Inhibits Osteoclast Formation and Activity in In Vitro Models for Periodontitis
por: Tao, Lucy Y., et al.
Publicado: (2022)

The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins
por: Taniguchi, Yasushi
Publicado: (2016)

Association of Distinct Fine Specificities of Anti−Citrullinated Peptide Antibodies With Elevated Immune Responses to Prevotella intermedia in a Subgroup of Patients With Rheumatoid Arthritis and Periodontitis
por: Schwenzer, Anja, et al.
Publicado: (2017)

BET bromodomain inhibition suppresses T(H)17-mediated pathology
por: Mele, Deanna A., et al.
Publicado: (2013)

BET bromodomain protein inhibition is a therapeutic option for medulloblastoma
por: Henssen, Anton, et al.
Publicado: (2013)

Dietary Compound Resveratrol Is a Pan-BET Bromodomain Inhibitor
por: Dutra, Luiz Antonio, et al.
Publicado: (2017)

BET bromodomain proteins regulate enhancer function during adipogenesis
por: Brown, Jonathan D., et al.
Publicado: (2018)

BET Bromodomain Inhibitors: Novel Design Strategies and Therapeutic Applications
por: To, Kenneth K. W., et al.
Publicado: (2023)

Metabolic rewiring in MYC-driven medulloblastoma by BET-bromodomain inhibition
por: Graziani, Vittoria, et al.
Publicado: (2023)

An Evaluation of Halitosis using Oral Chroma™ Data Manager, Organoleptic Scores and Patients’ Subjective Opinions
por: Dudzik, Agata, et al.
Publicado: (2015)

Therapeutic Targeting of BET Bromodomain Proteins in Castration-Resistant Prostate Cancer
por: Asangani, Irfan A., et al.
Publicado: (2014)

Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer
por: Wyce, Anastasia, et al.
Publicado: (2013)

Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery
por: Fu, Lei-lei, et al.
Publicado: (2015)

BET Bromodomain Blockade Mitigates Intimal Hyperplasia in Rat Carotid Arteries
por: Wang, Bowen, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_dit83nat69bhukonql1r1lsv60