In mice transgenic for IGF1 under keratin-14 promoter, lifespan is decreased and the rates of aging and thymus involution are accelerated

IGF1 signaling is supposedly a key lifespan determinant in metazoans. However, controversial lifespan data were obtained with different means used to modify IGF1 or its receptor (IGF1R) expression in mice. The emerging puzzle lacks pieces of evidence needed to construct a coherent picture. We add to...

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Detalles Bibliográficos
Autores principales: Anisimov, Vladimir N., Labunets, Irina F., Popovich, Irina G., Tyndyk, Margarita L., Yurova, Maria N., Golubev, Alexey G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503882/
https://www.ncbi.nlm.nih.gov/pubmed/30981207
http://dx.doi.org/10.18632/aging.101903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503882/
https://www.ncbi.nlm.nih.gov/pubmed/30981207
http://dx.doi.org/10.18632/aging.101903

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