TXNIP mediates high glucose-induced mitophagic flux and lysosome enlargement in human retinal pigment epithelial cells

Thioredoxin-interacting protein (TXNIP) plays a critical role in oxidative stress, inflammation, apoptosis and the pathogenesis of diabetic retinopathy (DR). However, the role of TXNIP in high glucose-induced retinal pigment epithelium (RPE) dysfunction is still unknown. Here, we show that high gluc...

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Detalles Bibliográficos
Autores principales: Devi, Takhellambam S., Yumnamcha, Thangal, Yao, Fayi, Somayajulu, Mallika, Kowluru, Renu A., Singh, Lalit P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503994/
https://www.ncbi.nlm.nih.gov/pubmed/31023645
http://dx.doi.org/10.1242/bio.038521

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503994/
https://www.ncbi.nlm.nih.gov/pubmed/31023645
http://dx.doi.org/10.1242/bio.038521

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