Single-cell imaging of CAR T cell activity in vivo reveals extensive functional and anatomical heterogeneity

CAR T cells represent a potentially curative strategy for B cell malignancies. However, the outcome and dynamics of CAR T cell interactions in distinct anatomical sites are poorly understood. Using intravital imaging, we tracked interactions established by anti-CD19 CAR T cells in B cell lymphoma–be...

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Detalles Bibliográficos
Autores principales: Cazaux, Marine, Grandjean, Capucine L., Lemaître, Fabrice, Garcia, Zacarias, Beck, Richard J., Milo, Idan, Postat, Jérémy, Beltman, Joost B., Cheadle, Eleanor J., Bousso, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504219/
https://www.ncbi.nlm.nih.gov/pubmed/30936262
http://dx.doi.org/10.1084/jem.20182375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504219/
https://www.ncbi.nlm.nih.gov/pubmed/30936262
http://dx.doi.org/10.1084/jem.20182375

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