Cargando…

Single-cell imaging of CAR T cell activity in vivo reveals extensive functional and anatomical heterogeneity

CAR T cells represent a potentially curative strategy for B cell malignancies. However, the outcome and dynamics of CAR T cell interactions in distinct anatomical sites are poorly understood. Using intravital imaging, we tracked interactions established by anti-CD19 CAR T cells in B cell lymphoma–be...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cazaux, Marine, Grandjean, Capucine L., Lemaître, Fabrice, Garcia, Zacarias, Beck, Richard J., Milo, Idan, Postat, Jérémy, Beltman, Joost B., Cheadle, Eleanor J., Bousso, Philippe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504219/ https://www.ncbi.nlm.nih.gov/pubmed/30936262 http://dx.doi.org/10.1084/jem.20182375

Ejemplares similares

Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4(+) CAR T-cell antitumor activity
por: Boulch, Morgane, et al.
Publicado: (2023)

Imaging the mechanisms of anti-CD20 therapy in vivo uncovers spatiotemporal bottlenecks in antibody-dependent phagocytosis
por: Grandjean, Capucine L., et al.
Publicado: (2021)

Quorum Sensing by Monocyte-Derived Populations
por: Postat, Jérémy, et al.
Publicado: (2019)

Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division
por: Bohineust, Armelle, et al.
Publicado: (2018)

Optogenetic manipulation of calcium signals in single T cells in vivo
por: Bohineust, Armelle, et al.
Publicado: (2020)

A major role for CD4(+) T cells in driving cytokine release syndrome during CAR T cell therapy
por: Boulch, Morgane, et al.
Publicado: (2023)

Intravital imaging reveals improved Kupffer cell-mediated phagocytosis as a mode of action of glycoengineered anti-CD20 antibodies
por: Grandjean, Capucine L., et al.
Publicado: (2016)

High resolution microfluidic assay and probabilistic modeling reveal cooperation between T cells in tumor killing
por: Ronteix, Gustave, et al.
Publicado: (2022)

Heterogeneous, delayed-onset killing by multiple-hitting T cells: Stochastic simulations to assess methods for analysis of imaging data
por: Beck, Richard J., et al.
Publicado: (2020)

CD19 CAR T Cells Expressing IL-12 Eradicate Lymphoma in Fully Lymphoreplete Mice through Induction of Host Immunity
por: Kueberuwa, Gray, et al.
Publicado: (2017)

CD4 T cells integrate signals delivered during successive DC encounters in vivo
por: Celli, Susanna, et al.
Publicado: (2005)

Spatiotemporal dynamics of calcium signals during neutrophil cluster formation
por: Khazen, Roxana, et al.
Publicado: (2022)

Integration of intermittent calcium signals in T cells revealed by temporally patterned optogenetics
por: Corre, Béatrice, et al.
Publicado: (2023)

Mathematical Modelling Based on In Vivo Imaging Suggests CD137-Stimulated Cytotoxic T Lymphocytes Exert Superior Tumour Control Due to an Enhanced Antimitotic Effect on Tumour Cells
por: Beck, Richard J., et al.
Publicado: (2021)

Heritable tumor cell division rate heterogeneity induces clonal dominance
por: Palm, Margriet M., et al.
Publicado: (2018)

Preclinical Assessment of CAR T-Cell Therapy Targeting the Tumor Antigen 5T4 in Ovarian Cancer
por: Owens, Gemma L., et al.
Publicado: (2018)

Mathematical modeling identifies LAG3 and HAVCR2 as biomarkers of T cell exhaustion in melanoma
por: Beck, Richard J., et al.
Publicado: (2023)

speedingCARs: accelerating the engineering of CAR T cells by signaling domain shuffling and single-cell sequencing
por: Castellanos-Rueda, Rocío, et al.
Publicado: (2022)

CAR-macrophage: An extensive immune enhancer to fight cancer
por: Wang, Shuhang, et al.
Publicado: (2022)

SSTR2 as an anatomical imaging marker and a safety switch to monitor and manage CAR T cell toxicity
por: Alcaina, Yago, et al.
Publicado: (2022)

Universal CARs, universal T cells, and universal CAR T cells
por: Zhao, Juanjuan, et al.
Publicado: (2018)

A plea for extension of the anatomical nomenclature: Vessels
por: Kachlik, David, et al.
Publicado: (2021)

Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells
por: Sumaria, Nital, et al.
Publicado: (2017)

CellSighter: a neural network to classify cells in highly multiplexed images
por: Amitay, Yael, et al.
Publicado: (2023)

Horses for Courses in the Era of CARs: Advancing CAR T and CAR NK Cell Therapies
por: Kulemzin, Sergey, et al.
Publicado: (2021)

CAR-Macrophages and CAR-T Cells Synergistically Kill Tumor Cells In Vitro
por: Liu, Maoxuan, et al.
Publicado: (2022)

Anatomic location and route of extension of the trigeminal nerve schwannomas
por: Natsis, Konstantinos, et al.
Publicado: (2015)

The development of CAR design for tumor CAR-T cell therapy
por: Xu, Dandan, et al.
Publicado: (2018)

CAR-T Regulatory (CAR-Treg) Cells: Engineering and Applications
por: Arjomandnejad, Motahareh, et al.
Publicado: (2022)

Clinical trials of dual-target CAR T cells, donor-derived CAR T cells, and universal CAR T cells for acute lymphoid leukemia
por: Zhao, Juanjuan, et al.
Publicado: (2019)

Modeling interaction of Glioma cells and CAR T-cells considering multiple CAR T-cells bindings
por: Li, Runpeng, et al.
Publicado: (2023)

Chemotactic Migration of T Cells towards Dendritic Cells Promotes the Detection of Rare Antigens
por: Vroomans, Renske M. A., et al.
Publicado: (2012)

Engineering CAR-T cells
por: Zhang, Cheng, et al.
Publicado: (2017)

CAR-T Cell Therapy
por: Ahmad, Aamir
Publicado: (2020)

Anti-CAR-engineered T cells for epitope-based elimination of autologous CAR T cells
por: Koristka, Stefanie, et al.
Publicado: (2019)

Allogeneic CAR T Cells: An Alternative to Overcome Challenges of CAR T Cell Therapy in Glioblastoma
por: Martínez Bedoya, Darel, et al.
Publicado: (2021)

CAR T cell therapy becomes CHIC: “cytokine help intensified CAR” T cells
por: Thomas, Simone, et al.
Publicado: (2023)

CAR Talk: How Cancer-Specific CAR T Cells Can Instruct How to Build CAR T Cells to Cure HIV
por: Kim, Gloria B., et al.
Publicado: (2019)

CARs and Drugs: Pharmacological Ways of Boosting CAR-T-Cell Therapy
por: Harrer, Dennis Christoph, et al.
Publicado: (2023)

Quantifying the contribution of transcription factor activity, mutations and microRNAs to CD274 expression in cancer patients
por: Bruns, Imke B., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8j6ddkpvukki18d982o8ljvfs4