Re-expression of SynGAP protein in adulthood improves translatable measures of brain function and behavior

It remains unclear to what extent neurodevelopmental disorder (NDD) risk genes retain functions into adulthood and how they may influence disease phenotypes. SYNGAP1 haploinsufficiency causes a severe NDD defined by autistic traits, cognitive impairment, and epilepsy. To determine if this gene retai...

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Detalles Bibliográficos
Autores principales: Creson, Thomas K, Rojas, Camilo, Hwaun, Ernie, Vaissiere, Thomas, Kilinc, Murat, Jimenez-Gomez, Andres, Holder, Jimmy Lloyd, Tang, Jianrong, Colgin, Laura L, Miller, Courtney A, Rumbaugh, Gavin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504227/
https://www.ncbi.nlm.nih.gov/pubmed/31025938
http://dx.doi.org/10.7554/eLife.46752

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504227/
https://www.ncbi.nlm.nih.gov/pubmed/31025938
http://dx.doi.org/10.7554/eLife.46752

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