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Reduction of Leukocyte Microvascular Adherence and Preservation of Blood-Brain Barrier Function by Superoxide-Lowering Therapies in a Piglet Model of Neonatal Asphyxia

Background: Asphyxia is the most common cause of brain damage in newborns. Substantial evidence indicates that leukocyte recruitment in the cerebral vasculature during asphyxia contributes to this damage. We tested the hypothesis that superoxide radical ([Formula: see text]) promotes an acute post-a...

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Detalles Bibliográficos
Autores principales: Ruden, Jacob B., Quick, Kevin L., Gonzales, Ernesto R., Shah, Aarti R., Park, T. S., Kennedy, Nan, Dugan, Laura L., Gidday, Jeffrey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504682/
https://www.ncbi.nlm.nih.gov/pubmed/31118919
http://dx.doi.org/10.3389/fneur.2019.00447