High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a thiazole scaffold which kills erythrocytic and sexual stage parasites

Antimalarial drug resistance compels the quest for new compounds that target alternative pathways to current drugs. The Plasmodium cyclic GMP-dependent protein kinase (PKG) has essential functions in all of the major life cycle developmental stages. An imidazopyridine PKG inhibitor scaffold was prev...

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Detalles Bibliográficos
Autores principales: Penzo, Maria, de las Heras-Dueña, Laura, Mata-Cantero, Lydia, Diaz-Hernandez, Beatriz, Vazquez-Muñiz, Maria-Jesus, Ghidelli-Disse, Sonja, Drewes, Gerard, Fernandez-Alvaro, Elena, Baker, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504873/
https://www.ncbi.nlm.nih.gov/pubmed/31065005
http://dx.doi.org/10.1038/s41598-019-42801-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504873/
https://www.ncbi.nlm.nih.gov/pubmed/31065005
http://dx.doi.org/10.1038/s41598-019-42801-x

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