Specific targeting of PKCδ suppresses osteoclast differentiation by accelerating proteolysis of membrane-bound macrophage colony-stimulating factor receptor

c-Fms is the macrophage colony-stimulating factor (M-CSF) receptor, and intracellular signalling via the M-CSF/c-Fms axis mediates both innate immunity and bone remodelling. M-CSF-induced transient proteolytic degradation of c-Fms modulates various biological functions, and protein kinase C (PKC) si...

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Detalles Bibliográficos
Autores principales: Kim, Mi Yeong, Lee, Kyunghee, Shin, Hong-In, Jeong, Daewon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504882/
https://www.ncbi.nlm.nih.gov/pubmed/31065073
http://dx.doi.org/10.1038/s41598-019-43501-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504882/
https://www.ncbi.nlm.nih.gov/pubmed/31065073
http://dx.doi.org/10.1038/s41598-019-43501-2

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