Epigenetic silencing of miR-340-5p in multiple myeloma: mechanisms and prognostic impact

BACKGROUND: miR-340-5p, localized to 5q35, is a tumor suppressor miRNA implicated in multiple cancers. As a CpG island is present at the putative promoter region of its host gene, RNF130, we hypothesized that the intronic miR-340-5p is a tumor suppressor miRNA epigenetically silenced by promoter DNA...

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Detalles Bibliográficos
Autores principales: Li, Zhenhai, Wong, Kwan Yeung, Calin, George A., Chng, Wee-Joo, Chan, Godfrey Chi-fung, Chim, Chor Sang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505104/
https://www.ncbi.nlm.nih.gov/pubmed/31064412
http://dx.doi.org/10.1186/s13148-019-0669-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505104/
https://www.ncbi.nlm.nih.gov/pubmed/31064412
http://dx.doi.org/10.1186/s13148-019-0669-2

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