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Epigenetic silencing of miR-340-5p in multiple myeloma: mechanisms and prognostic impact
BACKGROUND: miR-340-5p, localized to 5q35, is a tumor suppressor miRNA implicated in multiple cancers. As a CpG island is present at the putative promoter region of its host gene, RNF130, we hypothesized that the intronic miR-340-5p is a tumor suppressor miRNA epigenetically silenced by promoter DNA...
Autores principales: | Li, Zhenhai, Wong, Kwan Yeung, Calin, George A., Chng, Wee-Joo, Chan, Godfrey Chi-fung, Chim, Chor Sang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505104/ https://www.ncbi.nlm.nih.gov/pubmed/31064412 http://dx.doi.org/10.1186/s13148-019-0669-2 |
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