An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials

Species differences in drug metabolism and disposition can confound the extrapolation of in vivo PK data to man and also profoundly compromise drug efficacy studies owing to differences in pharmacokinetics, in metabolites produced (which are often pharmacologically active), and in differential activ...

Descripción completa

Detalles Bibliográficos
Autores principales: Henderson, C.J., Kapelyukh, Y., Scheer, N., Rode, A., McLaren, AW., MacLeod, A.K., Lin, D., Wright, J., Stanley, L.A., Wolf, C.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505380/
https://www.ncbi.nlm.nih.gov/pubmed/30910785
http://dx.doi.org/10.1124/dmd.119.086397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505380/
https://www.ncbi.nlm.nih.gov/pubmed/30910785
http://dx.doi.org/10.1124/dmd.119.086397

Ejemplares similares