Recapitulating Parkinson's disease pathology in a three-dimensional human neural cell culture model

Extensive loss of dopaminergic neurons and aggregation of the protein α-synuclein into ubiquitin-positive Lewy bodies represents a major neuropathological hallmark of Parkinson's disease (PD). At present, the generation of large nuclear-associated Lewy bodies from endogenous wild-type α-synucle...

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Detalles Bibliográficos
Autores principales: Taylor-Whiteley, Teresa R., Le Maitre, Christine L., Duce, James A., Dalton, Caroline F., Smith, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Resource Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505482/
https://www.ncbi.nlm.nih.gov/pubmed/30926586
http://dx.doi.org/10.1242/dmm.038042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505482/
https://www.ncbi.nlm.nih.gov/pubmed/30926586
http://dx.doi.org/10.1242/dmm.038042

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