Differential Methylation of H3K79 Reveals DOT1L Target Genes and Function in the Cerebellum In Vivo

The disruptor of telomeric silencing 1-like (DOT1L) mediates methylation of histone H3 at position lysine 79 (H3K79). Conditional knockout of Dot1l in mouse cerebellar granule cells (Dot1l-cKO(Atoh1)) led to a smaller external granular layer with fewer precursors of granule neurons. Dot1l-cKO(Atoh1)...

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Detalles Bibliográficos
Autores principales: Bovio, Patrick Piero, Franz, Henriette, Heidrich, Stefanie, Rauleac, Tudor, Kilpert, Fabian, Manke, Thomas, Vogel, Tanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505521/
https://www.ncbi.nlm.nih.gov/pubmed/30302725
http://dx.doi.org/10.1007/s12035-018-1377-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505521/
https://www.ncbi.nlm.nih.gov/pubmed/30302725
http://dx.doi.org/10.1007/s12035-018-1377-1

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