Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk

Genetic variants affecting pancreatic islet enhancers are central to T2D risk, but the gene targets of islet enhancer activity are largely unknown. We generate a high-resolution map of islet chromatin loops using Hi-C assays in three islet samples and use loops to annotate target genes of islet enha...

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Detalles Bibliográficos
Autores principales: Greenwald, William W., Chiou, Joshua, Yan, Jian, Qiu, Yunjiang, Dai, Ning, Wang, Allen, Nariai, Naoki, Aylward, Anthony, Han, Jee Yun, Kadakia, Nikita, Regue, Laura, Okino, Mei-Lin, Drees, Frauke, Kramer, Dana, Vinckier, Nicholas, Minichiello, Liliana, Gorkin, David, Avruch, Joseph, Frazer, Kelly A., Sander, Maike, Ren, Bing, Gaulton, Kyle J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505525/
https://www.ncbi.nlm.nih.gov/pubmed/31064983
http://dx.doi.org/10.1038/s41467-019-09975-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505525/
https://www.ncbi.nlm.nih.gov/pubmed/31064983
http://dx.doi.org/10.1038/s41467-019-09975-4

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