Characterization of cancer-associated IDH2 mutations that differ in tumorigenicity, chemosensitivity and 2-hydroxyglutarate production

The family of isocitrate dehydrogenase (IDH) enzymes is vital for cellular metabolism, as IDH1 and IDH2 are required for the decarboxylation of isocitrate to α-ketoglutarate. Heterozygous somatic mutations in IDH1 or IDH2 genes have been detected in many cancers. They share the neomorphic production...

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Detalles Bibliográficos
Autores principales: Kotredes, Kevin P., Razmpour, Roshanak, Lutton, Evan, Alfonso-Prieto, Mercedes, Ramirez, Servio H., Gamero, Ana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505628/
https://www.ncbi.nlm.nih.gov/pubmed/31105869
http://dx.doi.org/10.18632/oncotarget.26848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505628/
https://www.ncbi.nlm.nih.gov/pubmed/31105869
http://dx.doi.org/10.18632/oncotarget.26848

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